Cognitive Therapy for Recurrent Depression

• Status: Completed
• Trial end date: 2008-07-01
• Target enrollment: 0
• Participant gender: All

Summary

This study determined the effectiveness of continuation phase cognitive therapy versus antidepressant medication in preventing relapse of depression in people with recurrent depression.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute of Mental Health (NIMH); University of Texas Southwestern Medical Center
• Collaborator: National Institute of Mental Health (NIMH)
• Treatments: Fluoxetine

Criteria

Inclusion Criteria:

• Recurrent unipolar major depressive disorder

• Have experienced at least two episodes of major depression

• Have experienced at least one period of recovery during a depressive episode or have a history of dysthymia (a mood disorder characterized by depression) prior to the onset of current or past depressive episodes

• Willing and able to comply with all study requirements

• Able to speak and read English

Exclusion Criteria:

• Active alcohol or other substance dependence within 6 months prior to study entry

• Currently at risk for suicide

• Mood disorders due to a medical condition or substance abuse

• Bipolar, schizoaffective, obsessive compulsive, or eating disorders

• Schizophrenia

• Unable to stop mood-altering medications

• Current use of medication or diagnosis of a medical disorder that may cause depression (e.g., diabetes, head injury, stroke, cancer, multiple sclerosis)

• Previous failure to experience a reduction in depressive symptoms after 8 weeks of cognitive therapy with a certified therapist

• Previous failure to experience a reduction in depressive symptoms after 6 weeks of 40 mg of Prozac

• Pregnancy or plan to become pregnant in the next 11-12 months

• Unable to attend clinic twice weekly during business hours

• Unable to complete questionnaires