Colchicine Prevents Myocardial Injury After Non-Cardiac Surgery Pilot Study
Status:
Unknown status
Trial end date:
2021-10-01
Target enrollment:
Participant gender:
Summary
Perioperative Myocardial Infarction (PMI) is a major contributor to perioperative mortality
and morbidity with overall incidence of 5-16% (1, 2). It is associated with increased 30-day
mortality of 11.6% vs 2.2% of patients without PMI in non-cardiac surgical patients (1).
However, its recognition and diagnosis remains challenging as the typical symptoms and
findings of ischemic MI may be masked by post-operative changes and pain management.
In this study, the investigators hope to determine if colchicine decreases the incidence of
MINS in high risk surgical patients undergoing non-cardiac surgery and optimally establish
colchicine as a viable therapy to improve perioperative cardiovascular outcome in those
patients.
Phase:
N/A
Details
Lead Sponsor:
University of British Columbia
Collaborators:
Providence Health & Services Vancouver Coastal Health