Colchicine Treatment for Chronic Shoulder Pain Related to Calcific Tendonitis
Status:
Unknown status
Trial end date:
2011-10-01
Target enrollment:
Participant gender:
Summary
Chronic pain due to calcific tendonitis of shoulder is a prevalent condition usually treated
with recurrent courses of NSAIDs, physical therapy or surgical interventions. Colchicine has
been reported to be effective in the acute attack of shoulder tendonitis, however, has never
been examined in controlled study in patients with chronic shoulder pain secondary to
calcific tendonitis. Eighty patients with chronic shoulder pain (at least 3 months duration)
due to calcific tendonitis will be randomized to receive colchicine 0.5 mg twice daily or
placebo (lactose capsules) for 4 months. At the end of this blinded part of the study,
patients who received placebo and did not improve, will be eligible to continue study in the
open mode for additional 4 months with study drug. Efficacy (VAS for shoulder pain, shoulder
range of motion and shoulder pain and disability index) and safety (blood tests) follow-ups
will be scheduled bi-monthly for all patients.