Colchicine for Patients With Chagas´ Disease( B1 Stage)

• Status: Unknown status
• Trial end date: 2021-01-05
• Target enrollment: 0
• Participant gender: All

Summary

This study evaluate the addition of colchicine in the treatment of patients with Chagas´disease.

Forty patients will receive colchicine while twenty patients will receive placebo

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Sao Paulo General Hospital
• Collaborator: Fundação de Amparo à Pesquisa do Estado de São Paulo
• Treatments: Colchicine

Criteria

Inclusion Criteria:

• Clinical and serological diagnosis of Chagas´disease ( Stage B1)

• Must be able to swallow tablets

Exclusion Criteria:

• myocardial infarction or coronary artery disease,

• diabetes mellitus,

• valvular disease,

• creatinine clearance <30 ml / kg / min

• contraindication to perform cardiac magnetic resonance imaging

• use of angiotensin converting enzyme inhibitors, angiotensin II receptor blockers and aldosterone blockers

• previous use of benzonidazole