Cold Induced Changes in White Adipose

• Status: Completed
• Trial end date: 2018-08-20
• Target enrollment: 0
• Participant gender: Female

Summary

An adaptation to a cold environment is a tendency to generate heat within our body. Some of this heat comes from our fat tissue. Although most fat tissue is "white fat", there are pockets deep within the body that are called "brown fat", which are specially adapted to burning fat and making heat. The investigator believes that our white fat, just underneath the surface of our skin, also has this property to burn fat and make heat, although not at the high level of brown fat. This study is to examine this fat-burning property of the white fat under the skin in response to seasons and to cold. Many such studies have been done in mice, but little has been done in humans.

There are a number of factors, including age, weight, and medical history, that may make a person eligible or ineligible to participate in this study. Certain medications could make a person ineligible, but if these medications can be safely altered, the individual may become eligible.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Philip Kern; University of Kentucky
• Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); National Institutes of Health (NIH)
• Treatments: Deuterium Oxide; Propranolol

Criteria

Inclusion Criteria:

• the lean subjects body mass index (BMI) < 27

• subjects with obesity/MetS (BMI 27-45 with IGT, IFG, or 3 features of MetS)

• Insulin resistance Fasting blood sugar >126, or 2 hr glu >200, but with A1C<7.5 (i.e. we will include subjects with T2DM on no meds and with good glycemic control)

• adequate platelet count (>100,000)

• hematocrit of >32

• stable weight

Exclusion Criteria:

• obese subjects (BMI > 45)

• anti-inflammatory drugs, β-blockers, any diabetes drugs or drugs known to affect adipose tissue

• an unstable medical condition

• coronary artery disease

• congestive heart failure

• heart block or a history of or any contraindication to a β-blocker.

• asthma

• previous stroke

• use of anticoagulants or aspirin

• pregnant or breastfeeding

• lifestyles involving absent or extreme temperature exposure (eg. homebound or institutionalized subjects, outdoor workers).