Colloid Pre-Loading on D-Dimer During Cesarean Section Under Spinal Anesthesia

• Status: Completed
• Trial end date: 2016-07-01
• Target enrollment: 0
• Participant gender: Female

Summary

Maternal hypotension is the most frequent complication of a spinal Anesthesia. The prevention of spinal hypotension appears more likely to decrease the frequency and severity of associated adverse maternal symptoms than the treatment of established hypotension. Intravenous fluid administration prior to spinal anesthesia for caesarean section is accepted standard practice. The choice of fluid depends on individual and institutional habit, material cost (crystalloid is considerably cheaper) and the perceived relative benefits and risks. Uncommon but potentially serious adverse effect of colloids is impaired coagulation. Although pregnancy is associated with hypercoagulability, little is known about the effects of colloid preloading on coagulation in pregnant patients.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Anesthetics; Atropine; Bupivacaine; Ephedrine; Fibrin fragment D; Hydroxyethyl Starch Derivatives; Morphine; Pharmaceutical Solutions; Pseudoephedrine

Criteria

Inclusion Criteria:

• American Society of Anesthesiologist (ASA) status I or II

• Aged >18 years

• Singleton pregnancy

• Gestational age ≥ 37 weeks

• Height ≥ 150 cm and ≤ 180 cm

• Weight > 50 kg and < 100 kg

• Eligible for spinal anesthesia

• Elective cesarean delivery

Exclusion Criteria:

• Multiple pregnancies

• Cardiovascular disease cerebrovascular disease

• Diabetes Mellitus

• Hematological problems

• Abnormal coagulation tests

• Anticoagulant use

• Hemorrhagic syndromes of pregnancy (placenta previa or accidental hemorrhage)

• Regular NSAIDS treatment

• HELLP syndrome

• Severe preeclampsia

• Eclampsia

• Termination of pregnancy for any cause

• Peripheral neuropathy or chronic pain syndrome

• Local infection or injury at the needle entry point

• Known hypersensitivity reaction to local anesthetic, starch allergy

• Height < 150 cm and > 180 cm

• Weight < 50 kg and > 100 kg

• Patient refusing spinal anesthesia

• Fetal anomalies

• Fetal distress or cases with umbilical cord prolapsed