Combination Antibiotic Treatment for Reactive Arthritis Caused by Chlamydia Bacteria

• Status: Completed
• Trial end date: 2008-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Reactive arthritis, also known as Reiter's syndrome, is a form of arthritis that occurs as a reaction to an infection elsewhere in the body. It is characterized by inflammation of the joints, tendons, urogenital tract, and eyes. Pain and swelling in the knees, ankles, and feet are common. This study will determine the effectiveness of antibiotic therapy in treating people with chlamydia-induced reactive arthritis that has lasted for more than 6 months.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of South Florida
• Collaborator: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
• Treatments: Anti-Bacterial Agents; Azithromycin; Doxycycline; Rifampin

Criteria

Inclusion Criteria:

• Meet the following European Spondyloarthropathy Study Group Criteria:

1. inflammatory spinal pain OR

2. synovitis AND

3. one or more of the following:

1. positive family history

2. urethritis or cervicitis within 1 month prior to onset of arthritis

3. buttock pain

4. enthesopathy

5. sacroiliitis

• Disease duration of at least 6 months

• Negative pregnancy test at study baseline and willing to use an effective method of contraception other than combined oral contraceptives for the duration of the study (for women of childbearing age)

Exclusion Criteria:

• Sensitivity or history of allergic reaction to rifampin, doxycycline, or azithromycin

• Currently taking any medications that may interact with the study medications, specifically rifampin

• Liver transaminases greater than or equal to two times the normal level

• Significant abnormalities in the complete blood count (CBC)

• Pregnant

• Current psoriasis

• Diagnosis of inflammatory bowel disease

• Diagnosis of ankylosing spondylitis

• Previous prolonged exposure to antibiotics (more than 2 weeks) as a potential treatment for reactive arthritis