Overview
Combination Chemotherapy Before Surgery in Treating Patients With Mesothelioma of the Lung
Status:
Completed
Completed
Trial end date:
2003-08-01
2003-08-01
Target enrollment:
0
0
Participant gender:
All
All
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving chemotherapy drugs before surgery may shrink the tumor so that it can be removed during surgery. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy in treating patients who have mesothelioma of the lung.Phase:
Phase 2Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Swiss Group for Clinical Cancer ResearchTreatments:
Gemcitabine
Criteria
DISEASE CHARACTERISTICS:- Histologically and clinically confirmed pleural mesothelioma
- Stages T1-3, N0-2, M0 by CT scan of the chest
- Mediastinoscopy required for staging of mediastinal lymph nodes
- Considered completely resectable
PATIENT CHARACTERISTICS:
Age:
- Over 18
Performance status:
- WHO 0-2
Life expectancy:
- Not specified
Hematopoietic:
- Not specified
Hepatic:
- No severe liver disease
Renal:
- Creatinine no greater than 1.7 mg/dL
Cardiac:
- Adequate cardiac function
- No cardiac disease that would preclude forced hydration or surgery
Pulmonary:
- Predicted postoperative FEV_1 greater than 1 by spirometry
Other:
- No contraindication to surgery
- No other prior or concurrent malignancy except adequately treated carcinoma in situ of
the cervix or basal cell or squamous cell skin cancer
- No uncontrolled infection
- No uncontrolled diabetes
- No neurologic or psychiatric disorders that would preclude study compliance
- No other serious illnesses that would preclude study participation
- No other circumstances that would preclude study participation
PRIOR CONCURRENT THERAPY:
Biologic therapy
- Not specified
Chemotherapy
- Not specified
Endocrine therapy
- Not specified
Radiotherapy
- Not specified
Surgery
- No prior pleurectomy or lung resection except for diagnostic purposes