Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Germ Cell Tumors
Status:
Completed
Trial end date:
2009-04-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as paclitaxel, ifosfamide, carboplatin, and
etoposide work in different ways to stop the growth of tumor cells, either by killing them or
by stopping them from dividing. Giving chemotherapy with a peripheral stem cell transplant
may allow more chemotherapy to be given so that more tumor cells are killed.
The design of this trial is a phase I/II trial of sequential accelerated chemotherapy cycles
with taxol/ifosfamide and carboplatin/etoposide administered with G-CSF and PBSC support.
PURPOSE: The purpose of this study is to determine the effects of an intensive sequence of
chemotherapy drugs in patients with metastatic germ cell cancer. All of these chemotherapy
drugs are known to be active in this disease.