Overview

Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Primary CNS Lymphoma

Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining radiation therapy with chemotherapy may kill more cancer cells. PURPOSE: Phase II trial to study the effectiveness of methotrexate and cytarabine plus radiation therapy in treating patients who have primary CNS lymphoma.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
European Organisation for Research and Treatment of Cancer - EORTC
Treatments:
Cytarabine
Methotrexate
Criteria
DISEASE CHARACTERISTICS: Histologically proven non-Hodgkin's lymphoma of the central
nervous system (CNS) including leptomeninges and the spinal cord No Burkitt's lymphoma or
low grade T-cell lymphoma Must have at least 1 measurable lesion No AIDS-related primary
central nervous system lymphoma (PCNSL) No disease confined to the eye without other
localization in the CNS

PATIENT CHARACTERISTICS: Age: 16 to 60 Performance status: Karnofsky 40-100% Neurological
functional status 0-3 Life expectancy: Not specified Hematopoietic: Not specified Hepatic:
No serious impairment of hepatic function Renal: No serious impairment of renal function
Creatinine no greater than 1.5 mg/dL OR Creatinine clearance no less than 50 mL/min
Cardiovascular: No serious impairment of cardiac function Other: HIV negative No congenital
or acquired immunodeficiency syndrome No prior/concurrent systemic lymphoma No prior
malignancy except: Adequately treated non-melanoma skin cancer Carcinoma in situ of the
cervix uteri Not pregnant No severe uncontrolled infection

PRIOR CONCURRENT THERAPY: Biologic therapy: No concurrent treatment with immunosuppressive
drug Chemotherapy: No prior chemotherapy Endocrine therapy: Corticosteroid use for less
than 3 weeks allowed Radiotherapy: Not specified Surgery: No prior organ transplantation