Overview

Combination Chemotherapy With or Without Donor Bone Marrow Transplantation in Treating Infants With Previously Untreated Acute Lymphoblastic Leukemia

Status:
Completed
Trial end date:
2006-04-01
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Giving the drugs in different combinations may kill more cancer cells. Bone marrow transplantation allows the doctor to give higher doses of chemotherapy and kill more cancer cells. PURPOSE: Phase II trial to compare the effectiveness of combination chemotherapy with or without donor bone marrow transplantation in treating infants who have previously untreated acute lymphoblastic leukemia.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Children's Oncology Group
Collaborator:
National Cancer Institute (NCI)
Treatments:
6-Mercaptopurine
Asparaginase
Cyclophosphamide
Cyclosporine
Cyclosporins
Cytarabine
Daunorubicin
Dexamethasone
Doxorubicin
Liposomal doxorubicin
Mercaptopurine
Methotrexate
Methylprednisolone
Methylprednisolone acetate
Methylprednisolone Hemisuccinate
Pegaspargase
Prednisolone
Prednisolone acetate
Prednisolone hemisuccinate
Prednisolone phosphate
Thioguanine
Vincristine
Criteria
DISEASE CHARACTERISTICS:

- Diagnosis of previously untreated acute lymphoblastic leukemia (ALL) or acute
undifferentiated leukemia

- CNS or testicular disease allowed

- No L3 sIg+ ALL or acute myelogenous leukemia

- At least 36 weeks gestation for congenital ALL

PATIENT CHARACTERISTICS:

Age:

- Under 366 days at diagnosis

Performance status:

- Not specified

Life expectancy:

- Not specified

Hematopoietic:

- Not specified

Hepatic:

- Not specified

Renal:

- Not specified

PRIOR CONCURRENT THERAPY:

Biologic therapy:

- Not specified

Chemotherapy:

- Not specified

Endocrine therapy:

- Steroid therapy within 48 hours of study allowed if complete blood counts and lumbar
puncture results known

- No chronic steroid treatment for other disease

Radiotherapy:

- Not specified

Surgery:

- Not specified

Other:

- No other concurrent cytotoxic therapy