Combination Chemotherapy With or Without Radiation Therapy in Treating Children With Brain Tumors

• Status: Unknown status
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving radiation therapy after chemotherapy may kill any remaining tumor cells.

PURPOSE: This phase II trial is studying how well giving combination chemotherapy together with or without radiation therapy works in treating children with brain tumors.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Children's Cancer and Leukaemia Group
• Treatments: Carboplatin; Cyclophosphamide; Methotrexate; Vincristine

Criteria

DISEASE CHARACTERISTICS:

• Diagnosis of 1 of the following:

• Brain stem tumor (histological confirmation not required)

• Histologically confirmed primary intracranial brain tumor of 1 of the following histologies:

• Anaplastic (malignant) astrocytoma

• Glioblastoma

• Anaplastic (malignant) oligodendroglioma

• Ependymoma

• Anaplastic (malignant) ependymoma

• Anaplastic (malignant) oligoastrocytoma

• Choroid plexus carcinoma

• Astroblastoma

• Polar spongioblastoma

• Gliomatosis cerebri

• Anaplastic (malignant) ganglioglioma

• Pineoblastoma

• Mixed pineocytoma or pineoblastoma

• Medulloepithelioma

• Neuroblastoma

• Ependymoblastoma

• Primitive neuroectodermal tumors (PNETs), including medulloblastoma or cerebral or spinal PNETs

• Has undergone surgery or biopsy of the tumor within the past 2-4 weeks

PATIENT CHARACTERISTICS:

• No concurrent unrelated disease, including hematological or renal disease, that would preclude study treatment

PRIOR CONCURRENT THERAPY:

• No prior chemotherapy or radiotherapy

• Prior steroids allowed

• No concurrent steroids as anti-emetics

• Concurrent steroids allowed for control of tumor-related symptoms