Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer
Status:
Completed
Trial end date:
2019-07-12
Target enrollment:
Participant gender:
Summary
RATIONALE: Giving chemotherapy drugs and total-body irradiation before a donor stem cell
helps stop the growth of cancer or abnormal cells. It may also stop the patient's immune
system from rejecting the donor's stem cells. When the healthy stem cells from a donor are
infused into the patient they may help the patient's bone marrow make stem cells, red blood
cells, white blood cells, and platelets. It is not yet known which combination chemotherapy
regimen is most effective when given before a donor stem cell transplant in treating aplastic
anemia or hematologic cancer.
PURPOSE: This phase II/III trial is studying different combination chemotherapy regimens to
compare how well they work when given before donor stem cell transplant in treating patients
with aplastic anemia or hematologic cancer.