Overview

Combination Chemotherapy in Treating Adults With Acute Lymphocytic Leukemia

Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. PURPOSE: Randomized phase II trial to study the effectiveness of various combination chemotherapy regimens in treating patients with acute lymphocytic leukemia.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Johann Wolfgang Goethe University Hospital
Treatments:
6-Mercaptopurine
Asparaginase
Cyclophosphamide
Cytarabine
Daunorubicin
Dexamethasone
Doxorubicin
Etoposide
Ifosfamide
Leucovorin
Levoleucovorin
Liposomal doxorubicin
Mercaptopurine
Methotrexate
Mitoxantrone
Prednisolone
Teniposide
Thioguanine
Vincristine
Vindesine
Criteria
DISEASE CHARACTERISTICS: Diagnosis of low-risk acute lymphocytic leukemia (ALL) (common ALL
or pre-B-cell) Must meet 1 of the following 2 conditions: Age 51 to 65 and meets the
following criteria: No mediastinal mass No T-cell or B-cell disease Age 15 to 50 and meets
the following criteria: Philadelphia chromosome (Ph) negative bcr-abl negative Initial WBC
less than 30,000/mm3 OR Diagnosis of T-cell ALL with or without mediastinal involvement Age
15 to 50 OR Diagnosis of high-risk ALL (common ALL or pre-B-cell) Age 15 to 50 and meets 1
of the following criteria: Ph positive bcr-abl positive Pre-pre-B-cell disease, i.e.,
t(4;11) Initial WBC greater than 30,000/mm3 OR Diagnosis of B-cell ALL

PATIENT CHARACTERISTICS: Age: See Disease Characteristics 15 to 65 Performance status: Not
specified Life expectancy: Not specified Hematopoietic: See Disease Characteristics
Hepatic: Not specified Renal: No renal failure Cardiovascular: No cardiomyopathy Other:
HIV-1 and HIV-2 negative No severe psychiatric disease

PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior cytostatic
drugs except vincristine Endocrine therapy: Prior corticosteroids allowed Radiotherapy: Not
specified Surgery: Not specified Other: No more than 2 weeks of prior therapy No other
prior cytostatic drugs