Overview

Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia

Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. It is not yet known which regimen of combination chemotherapy is more effective for childhood acute lymphoblastic leukemia. PURPOSE: This randomized phase III trial is comparing different regimens of combination chemotherapy to see how well they work in treating children with acute lymphoblastic leukemia.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Children's Oncology Group
Collaborator:
National Cancer Institute (NCI)
Treatments:
6-Mercaptopurine
Asparaginase
BB 1101
Calcium, Dietary
Cyclophosphamide
Cytarabine
Daunorubicin
Dexamethasone
Dexamethasone 21-phosphate
Dexamethasone acetate
Leucovorin
Levoleucovorin
Mercaptopurine
Methotrexate
Pegaspargase
Thioguanine
Vincristine
Criteria
DISEASE CHARACTERISTICS:

- Diagnosis of B-cell precursor acute lymphoblastic leukemia

- Registered on POG-9900 Classification Study

- Registered within 7 days of documenting complete response (CR) after induction therapy
on day 29 or, if 2 more weeks of induction are required, within 7 days of CR
determination

- Classified as low-risk:

- WBC less than 50,000/mm^3

- Age 1 to 9

- No adverse translocations [E2A-PBX1, t(1;19) or BCR/ABL, t(9;22); and MLL
rearrangements]

- No CNS 3 disease (CSF WBC at least 5/mm^3 with blasts present)

- No testicular disease

- At least one of the following present:

- TEL/AML1, t(12;21)

- Simultaneous trisomy of chromosomes 4 and 10

PATIENT CHARACTERISTICS:

Age:

- 1 to 9

Performance status:

- Not specified

Life expectancy:

- Not specified

Hematopoietic:

- See Disease Characteristics

Hepatic:

- Not specified

Renal:

- Not specified

Other:

- Not pregnant or nursing

- Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy

- Not specified

Chemotherapy

- Not specified

Endocrine therapy

- Not specified

Radiotherapy

- Not specified

Surgery

- Not specified