Overview
Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia
Status:
Completed
Completed
Trial end date:
1969-12-31
1969-12-31
Target enrollment:
0
0
Participant gender:
All
All
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. It is not yet known which regimen of combination chemotherapy is more effective for childhood acute lymphoblastic leukemia. PURPOSE: This randomized phase III trial is comparing different regimens of combination chemotherapy to see how well they work in treating children with acute lymphoblastic leukemia.Phase:
Phase 3Accepts Healthy Volunteers?
NoDetails
Lead Sponsor:
Children's Oncology GroupCollaborator:
National Cancer Institute (NCI)Treatments:
6-MercaptopurineAsparaginase
BB 1101
Calcium, Dietary
Cyclophosphamide
Cytarabine
Daunorubicin
Dexamethasone
Dexamethasone 21-phosphate
Dexamethasone acetate
Leucovorin
Levoleucovorin
Mercaptopurine
Methotrexate
Pegaspargase
Thioguanine
Vincristine
Criteria
DISEASE CHARACTERISTICS:- Diagnosis of B-cell precursor acute lymphoblastic leukemia
- Registered on POG-9900 Classification Study
- Registered within 7 days of documenting complete response (CR) after induction therapy
on day 29 or, if 2 more weeks of induction are required, within 7 days of CR
determination
- Classified as low-risk:
- WBC less than 50,000/mm^3
- Age 1 to 9
- No adverse translocations [E2A-PBX1, t(1;19) or BCR/ABL, t(9;22); and MLL
rearrangements]
- No CNS 3 disease (CSF WBC at least 5/mm^3 with blasts present)
- No testicular disease
- At least one of the following present:
- TEL/AML1, t(12;21)
- Simultaneous trisomy of chromosomes 4 and 10
PATIENT CHARACTERISTICS:
Age:
- 1 to 9
Performance status:
- Not specified
Life expectancy:
- Not specified
Hematopoietic:
- See Disease Characteristics
Hepatic:
- Not specified
Renal:
- Not specified
Other:
- Not pregnant or nursing
- Fertile patients must use effective contraception
PRIOR CONCURRENT THERAPY:
Biologic therapy
- Not specified
Chemotherapy
- Not specified
Endocrine therapy
- Not specified
Radiotherapy
- Not specified
Surgery
- Not specified