Overview

Combination Chemotherapy in Treating Children With Neuroblastoma

Status:
Completed
Trial end date:
2011-01-01
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. Combination chemotherapy plus surgery may be an effective treatment for neuroblastoma. PURPOSE: This phase III trial is studying how well combination chemotherapy followed by surgery works in treating young patients with neuroblastoma.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Children's Oncology Group
Collaborator:
National Cancer Institute (NCI)
Treatments:
Carboplatin
Cyclophosphamide
Doxorubicin
Etoposide
Lenograstim
Liposomal doxorubicin
Molgramostim
Sargramostim
Criteria
DISEASE CHARACTERISTICS:

- Histologically proven neuroblastoma or maturing ganglioneuroma that is judged to be
intermediate risk by one of the following criteria:

- International Neuroblastoma Staging System (INSS) stage III

- Under 1 year old, MYCN oncogene nonamplified, and any ploidy

- 1 to 20 years old, MYCN nonamplified, favorable Shimada histology

- INSS stage IV

- Under 1 year old, MYCN nonamplified, any ploidy

- INSS stage IVS

- Under 1 year old, MYCN nonamplified, unfavorable Shimada histology and any
ploidy OR favorable Shimada histology and diploidy

- All patients must be registered on the companion neuroblastoma biology study
(COG-ANBL00B1)

PATIENT CHARACTERISTICS:

Age:

- Under 21

Performance status:

- Not specified

Life expectancy:

- Not specified

Hematopoietic:

- Not specified

Hepatic:

- Not specified

Renal:

- Not specified

Other:

- No abnormal organ function that would prohibit chemotherapy unless due to
neuroblastoma

PRIOR CONCURRENT THERAPY:

Biologic therapy:

- Not specified

Chemotherapy:

- Prior chemotherapy for patients with intradural extension and emergent paresis allowed
provided biopsy was performed within 96 hours after treatment

Endocrine therapy:

- Not specified

Radiotherapy:

- Not specified

Surgery:

- Not specified

Other:

- No other prior therapy