Combination Chemotherapy in Treating Older Patients With Non-Hodgkin's Lymphoma

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.

PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy in treating older patients who have non-Hodgkin's lymphoma.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: European Organisation for Research and Treatment of Cancer - EORTC
• Treatments: Cyclophosphamide; Prednisone; Vincristine

Criteria

DISEASE CHARACTERISTICS:

• Diagnosis of diffuse large B-cell or peripheral T-cell non-Hodgkin's lymphoma (NHL)

• No Burkitt's-like lymphoma

• Small cells in bone marrow allowed

• Previously untreated NHL

• At least 1 measurable lesion

• At least 1.1 cm

• Poor physiological status with at least 1 of the following:

• WHO performance status of 3-4

• LVEF less than 50%

• Creatinine clearance less than 50 mL/min

• Neutrophil count no greater than 1,500/mm^3

• Platelet count no greater than 100,000/mm^3

• Concurrent severe disease that would preclude cyclophosphamide, vincristine, prednisolone, and doxorubicin

• No cerebral or meningeal involvement

PATIENT CHARACTERISTICS:

Age:

• 70 and over

Performance status:

• See Disease Characteristics

Life expectancy:

• Not specified

Hematopoietic:

• See Disease Characteristics

Hepatic:

• Not specified

Renal:

• See Disease Characteristics

Other:

• HIV negative

• No other malignancy within the past 5 years except adequately treated basal cell skin cancer, curatively treated carcinoma in situ of the cervix, or curatively treated solid tumor

• No active infection

• No psychological, familial, sociological, or geographical condition that would preclude study participation

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• Not specified

Chemotherapy:

• See Disease Characteristics

Endocrine therapy:

• Not specified

Radiotherapy:

• Not specified

Surgery:

• Not specified

Other:

• No other concurrent investigational drugs

• No other concurrent antineoplastic agents