Overview

Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia

Status:
Completed
Trial end date:
2006-09-01
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy in treating patients who have non-Hodgkin's lymphoma or acute lymphocytic leukemia.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Children's Oncology Group
Collaborator:
National Cancer Institute (NCI)
Treatments:
BB 1101
Cyclophosphamide
Cytarabine
Dexamethasone
Dexamethasone 21-phosphate
Dexamethasone acetate
Doxorubicin
Etoposide
Etoposide phosphate
Ifosfamide
Isophosphamide mustard
Lenograstim
Leucovorin
Levoleucovorin
Liposomal doxorubicin
Methotrexate
Vincristine
Criteria
DISEASE CHARACTERISTICS:

- One of the following diagnoses:

- Histologically confirmed small noncleaved cell non-Hodgkin's lymphoma

- Stage III or IV

- Burkitt's or non-Burkitt's by the Working Formulation OR

- Burkitt's or Burkitt's-like by the REAL classification

- Histologically confirmed B-cell acute lymphocytic leukemia

- At least 25% blasts in bone marrow

- FAB L3 morphology

- FAB L1 morphology allowed if blasts show B-cell markers (CD19, 20, 22) and
surface immunoglobulin positivity

- Must be registered on POG-9900 in past 8 days

PATIENT CHARACTERISTICS:

Age:

- Under 22 at time of diagnosis

Performance status:

- Not specified

Life expectancy:

- Not specified

Hematopoietic:

- Not specified

Hepatic:

- Not specified

Renal:

- Not specified

Other:

- Not pregnant or nursing

- Negative pregnancy test

- HIV positive allowed

PRIOR CONCURRENT THERAPY:

Biologic therapy:

- Not specified

Chemotherapy:

- Not specified

Endocrine therapy:

- No concurrent use of dexamethasone as antiemetic

Radiotherapy:

- Not specified

Surgery:

- Prior surgery allowed

Other:

- No prior therapy except surgery