Combination Dexamethasone and Bupivacaine Pain Control in Reduction Mammaplasty

• Status: Completed
• Trial end date: 2020-11-25
• Target enrollment: 0
• Participant gender: Female

Summary

The addition of dexamethasone to non-liposomal bupivacaine in perineural blocks has been shown to enhance pain control and prolong the time until first request for postoperative narcotics in the fields of orthopedic, thoracic, and gynecologic surgery. This has not been investigated in any types of breast surgery. The investigators assessed if the combination of dexamethasone to bupivacaine in the preoperative field block prior to bilateral breast reduction surgery resulted in improved pain control relative to bupivacaine alone.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Temple University
• Treatments: Dexamethasone

Criteria

Inclusion Criteria:

• Female

• Age 18-80

• Bilateral reduction mammaplasty

• American Society of Anesthesiologists (ASA) physical status classification 1, 2, or 3

• Must choose to receive preoperative nerve block as part of pain management strategy

Exclusion Criteria:

• Allergy to dexamethasone or bupivacaine

• History of postoperative nausea and vomiting following anesthesia

• History of chronic pain conditions

• History of narcotic abuse or dependency

• History of chronic renal disease

• History of chronic liver disease