Combination Gemcitabine, Carboplatin With or Without Trastuzumab in Patients With Metastatic Breast Cancer
Status:
Completed
Trial end date:
2008-10-01
Target enrollment:
Participant gender:
Summary
Pre-clinical data suggests that combination therapy with gemcitabine and carboplatin is
synergistic, and both drugs may be synergistic with trastuzumab. Additionally, recent
clinical data suggest that the combination of gemcitabine with platinum is an active regimen
in metastatic breast cancer. This study will test the combination of gemcitabine with
carboplatin in patients with metastatic breast cancer. Patients with Her2/neu overexpression
will be stratified to receive trastuzumab in addition to gemcitabine and carboplatin.