Overview

Combination Medications vs. Patch Alone for Medically-Ill Smokers

Status:
Completed
Trial end date:
2008-01-01
Target enrollment:
0
Participant gender:
All
Summary
Randomized clinical trial to evaluate a flexibly-dosed-3-medication combination for up to 6 months in smokers with medical illness
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Medicine and Dentistry of New Jersey
Collaborators:
Robert Wood Johnson Foundation
Rutgers Cancer Institute of New Jersey
Treatments:
Bupropion
Nicotine
Criteria
Inclusion Criteria:

- currently smoking at least 10 cigarettes per day (confirmed by high exhaled
carbon-monoxide (CO))

- 18 years or older

- interested in quitting within the next 30 days

- one or more pre-defined medical illnesses (including cardiovascular disease, other
vascular disease, chronic pulmonary disease, cancer, hypertension, diabetes,
hyperlipidemia, and recurrent pulmonary infections)

Exclusion Criteria:

- contraindications to pharmacotherapy (including unstable angina, myocardial infarction
within 2 months, severe arrhythmia, seizure disorder, serious mental illness requiring
antipsychotic medications)

- current use of other tobacco products (smokeless tobacco, cigars, pipes, etc.),
bupropion, clonidine, nortriptyline, or nicotine replacement medications

- unable to give consent