Combination Therapy With Fluoroquinolone in Staphylococcus Aureus Bacteremia

• Status: Completed
• Trial end date: 2002-08-01
• Target enrollment: 0
• Participant gender: All

Summary

To study whether fluoroquinolone (trovafloxacin or levofloxacin), added to standard treatment, could reduce the high mortality and complication rates in Staphylococcus aureus bacteremia.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Helsinki University; University of Helsinki
• Treatments: Alatrofloxacin; Fluoroquinolones; Levofloxacin; Ofloxacin; Trovafloxacin

Criteria

Inclusion Criteria:

Adult patients with at least 1 blood culture positive for Staphylococcus aureus were included within 1 to 7 days of blood culture sampling.

Exclusion Criteria:

• age younger than 18 years

• imprisonment

• proven or suspected pregnancy

• breastfeeding, epilepsy

• another bacteremia during the previous 28 days

• polymicrobial bacteremia (_>3 microbes)

• history of allergy to any quinolone antibiotic

• previous tendinitis during fluoroquinolone therapy

• prior fluoroquinolone use for more than 5 days before randomization

• positive culture for Staphylococcus aureus only from a central intravenous catheter

• neutropenia (<0.5 x 109/L) or failure to supply an informed consent

• patients with bacteremia due to methicillin-resistant S. aureus and a S. aureus strain resistant to any fluoroquinolone

• patients with meningitis at the time of randomization