Combination Therapy With Myo-inositol and Folic Acid Versus Myo-inositol Alone
Status:
Completed
Trial end date:
2013-12-01
Target enrollment:
Participant gender:
Summary
Previous studies have demonstrated that Myo-inositol is capable of restoring spontaneous
ovarian activity, and consequently fertility, in most patients with PCOS. The aim of our
study is to investigate the role of folic acid conteined in the inositol preparation. The
study group included 50 patients, randomly allocated to subgroup A (myo-inositol 1500 gr) and
subgroup B (myo-inositol 2000 gr + folic acid 200 mcg). The investigation include menstrual
pattern and hirsutism score evaluation, hormonal assays, oral glucose tolerance test,
euglycemic hyperinsulinaemic clamp and lipide profile at baseline and after six months of
treatment.