Combination Therapy in Dual Diagnosis Bipolar Rapid Cycling
Status:
Completed
Trial end date:
2007-12-01
Target enrollment:
Participant gender:
Summary
Combination Therapy in Dual Diagnosis Bipolar Rapid Cycling: This study recruits males and
females age 18 and older who currently meet diagnostic criteria for rapid cycling bipolar
disorder (type I or II) and who have met the criteria for substance abuse or dependence of
cocaine, marijuana and/or alcohol within the past six months. Patients begin treatment with a
combination of lithium and divalproex. Once these medications are tolerated, they are
randomly assigned to double-blind treatment with lamotrigine or placebo. Patients remain in
this study until they experience a marked bimodal response for four consecutive weeks. This
study is sponsored by the Stanley Foundation.