Combination Therapy of Hydroxyurea With L-Carnitine and Magnesium Chloride in Thalassemia Intermedia

• Status: Completed
• Trial end date: 2007-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is determination of the efficacy of combination of hydroxyurea with L-carnitine or magnesium in improving hematologic parameters and cardiac status in patients with β-thalassemia intermedia in comparison with hydroxyurea alone .

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shiraz University of Medical Sciences
• Treatments: Hydroxyurea

Criteria

Inclusion Criteria:

• Beta thalassemia intermedia patients with mean hemoglobin level >= 7gr/dl, need to blood transfusion with more than 6 months interval or no need to blood transfusion

Exclusion Criteria:

• Hypothyroidism

• Hypoparathyroidism

• Diabetes mellitus

• Hepatitis B and C

• Positive tests for human immunodeficiency virus

• Any cardiac symptoms or receiving drug for cardiac disease

• Presence of other hemoglobinopathies except thalassemia intermedia and pregnant or lactating womens