Combination of Continuous Femoral Block and Intravenous Parecoxib For Postoperative Analgesia After Total Knee Arthroplasty

• Status: Completed
• Trial end date: 2014-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Combination of continuous femoral block with parEcoxib vs placebo. Investigation of morphine consumption, opioid sparing effects, VAS pain scores, haemodynamics, Anxierty scores, transfusion requirements , Range of motion and rehabilitation parameters between two groups

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Asklepieion Voulas General Hospital
• Treatments: Parecoxib; Ropivacaine

Criteria

Inclusion Criteria:

• PATIENTS ASA I-II UNDERGOING TOTAL KNEE ATRTHROPLASTY

Exclusion Criteria:

Exclusion criteria for both groups included:

• Age younger than 40 years old or older than 80 years old

• ASA > III

• Obesity (>140 kg body weight)

• Allergy to local anesthetics

• History dependence on opioids

• Contraindications for subarachnoid anesthesia or femoral block (coagulopathy, local infection, pre-existing neurological problems, patient refusal)

• Contraindications to the administration of parecoxib

• Severe hepatic or renal disease (serum creatinine ≥ 1.7 mg/dl)