Combination of Thrombopoietin Mimetic and Immunosuppressive Therapy in Aplastic Anaemia

• Status: Completed
• Trial end date: 2021-06-01
• Target enrollment: 0
• Participant gender: All

Summary

To the investigator's Knowledge this is the first study that will assess Treatment with thrombopoietin Mimetic plus immunosuppressiveTherapy in Egyptian Patients with Aplastic Anaemia.

Aim of the work :

1. To evaluate the efficacy, tolerability and toxicity of the combination of thrombopoietin mimetic and immunosuppressive therapy in Egyptian patients with AA.

2. To study the influence of this combination on patients' quality of life.

3. To access evolution to paroxysmal nocturnal hemoglobinuria (PNH), myelodysplastic syndrome , acute leukemia or development of fibrosis

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University; Safaa AA Khaled
• Collaborator: Assiut University
• Treatments: Cyclosporine; Cyclosporins; Immunosuppressive Agents

Criteria

Inclusion Criteria:

• Eligible for treatment with thrombopoietin mimetic.

• Willing to participate in the study and signed informed consent.

• Unavailability of BMT -

Exclusion Criteria:

• Patient with inherited aplastic anemia

• Underlying immune deficiency

• Contra indication to cyclosporin A

• Endstage hepatic or renal disease

• Pregnancy and lactation