Combined Administration of Teripapartide and Antiresorptive Agents in Postmenopausal Osteoporosis
Status:
Completed
Trial end date:
2012-12-01
Target enrollment:
Participant gender:
Summary
Increased bone formation in the absence of accelerated resorption is resulting in a marked
anabolic response to teriparatide (TPTD) during the early phase after treatment initiation.
Months later, due to coupling mechanism, the sustained increase of bone formation and ongoing
anabolic effects are accompanied by significantly increased bone resorption as well.
Antiresorptives influence the balance of bone formation and resorption. Therefore the
investigators aim is to investigate the effects of the addition of antiresorptives to the
second half of TPTD cycle when resorption is already also markedly elevated.