Combined Antioxidant Therapy on Oxidative Stress in Aqueous and Vitreous Humor of Diabetic Retinopathy Patients
Status:
Recruiting
Trial end date:
2022-01-01
Target enrollment:
Participant gender:
Summary
The present study aims to support previous research on the effects of antioxidant therapy on
the outcome of diabetic retinopathy and local oxidative stress values. The researchers intend
to evaluate 56 patients with proliferative diabetic retinopathy undergoing the vitrectomy
procedure, who will be assigned to a placebo group or combination antioxidant therapy. Each
group will receive the intervention for 2 months. This intervention consists of taking one
tablet (placebo or antioxidant therapy) orally, once a day.
At the beginning of the study, only blood samples will be collected to evaluate the state of
oxidative and metabolic stress at a systemic level. After 2 months of intervention, blood
samples will be taken again on the day of the intervention, adding the samples of aqueous and
vitreous humor obtained during the vitrectomy. The results obtained between both groups and
the different analysis matrices will be compared.