Combined Donepezil and Selegiline Effects on Cocaine-Reinforced Behavior

• Status: Completed
• Trial end date: 2013-05-01
• Target enrollment: 0
• Participant gender: All

Summary

No medications are currently available for treatment of psychostimulant addiction, a compulsive preoccupation with use of cocaine and related compounds. Donepezil is a medication that is currently prescribed for Alzheimer's disease, and selegiline is a medication used for treatment of Parkinson's Disease. Both of these medications can decrease the amount of cocaine injections that laboratory animals choose to inject by vein. This project will determine if combined treatment with donepezil and selegiline can also decrease cocaine-motivated behavior for human subjects in a laboratory setting.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Midwest Biomedical Research Foundation
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Cocaine; Donepezil; Selegiline

Criteria

Inclusion Criteria:

• Meets DSM-IV-TR criteria for cocaine abuse or dependence

• At least one cocaine-positive urine within 6 weeks prior to enrollment

• Has used cocaine for a duration of at least 6 months

• At least weekly cocaine use during the last 30 days

Exclusion Criteria:

• History of a medical adverse reaction to cocaine or other psychostimulants

• Any current Axis I psychiatric disorder other than drug abuse or dependence

• Dependence on abused substances other than cocaine

• Current or past history of seizure disorder

• Heart or lung disease