Combined Donepezil and Selegiline Effects on Cocaine-Reinforced Behavior
Status:
Completed
Trial end date:
2013-05-01
Target enrollment:
Participant gender:
Summary
No medications are currently available for treatment of psychostimulant addiction, a
compulsive preoccupation with use of cocaine and related compounds. Donepezil is a medication
that is currently prescribed for Alzheimer's disease, and selegiline is a medication used for
treatment of Parkinson's Disease. Both of these medications can decrease the amount of
cocaine injections that laboratory animals choose to inject by vein. This project will
determine if combined treatment with donepezil and selegiline can also decrease
cocaine-motivated behavior for human subjects in a laboratory setting.