Combined Effect of Acitretin and Narrow Band Ultraviolet B on Vitiligo Repigmentation

• Status: Recruiting
• Trial end date: 2021-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Since abnormal keratinocyte (KC) proliferation and differentiation as well as defective E cadherin expression were reported in vitiligo lesions, the investigators set to study the potential efficacy of combining Retinoids, which are known to improve KC proliferation and differentiation and increase the expression of adhesion molecules, with narrowband UVB in the treatment of vitiligo.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Cairo University
• Treatments: Acitretin

Criteria

Inclusion Criteria:

• Patients with generalized non-segmental vitiligo (25%-75%)

• Males, postmenopausal females and premenopausal females not planning to get pregnant during the period of treatment and after 2 years from the end of treatment.

• Age more than 18 years.

Exclusion Criteria:

• Children ˂ 18 years old

• Pregnant females

• Premenopausal females planning to get pregnant within the period of treatment or within 2 years after.

• Patients receiving treatment for vitiligo within the past 2 months.

• Patients with abnormal liver profile

• Patients with abnormal lipid profile

• Patients with associated photosensitive disorders

• Patients having associated skin diseases other than vitiligo

• Cataract and aphakia

• High cumulative dose from previous sessions of narrowband ˃ 200-300 session