Combined Effect of Insulin and Sodium Hyaluronate Injection Guided by Ultrasound in Carpal Tunnel Syndrome

• Status: Unknown status
• Trial end date: 2020-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Carpal tunnel syndrome (CTS) is the most common peripheral entrapment neuropathy with involving compression of the median nerve in the carpal tunnel. The technique of perineural injection therapy (PIT) is now commonly used for peeling the nerve from surrounding soft tissue (called nerve hydrodissection), which may help to reduce neuro-inflammation, ischemic damage and allow impulse transmission.

The objective of this study is to evaluate the efficacy of ultrasound guided insulin plus Sodium Hyaluronate injection in reducing symptoms caused by carpal tunnel syndrome.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Hyaluronic Acid; Insulin; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

• Aged 18 to 65

• Understanding written and spoken Arabic consent

• Diagnostic of carpal tunnel syndrome: Classic of probable based on the Katz Hand Diagram and mild to moderate based on the electrodiagnosis studies

Exclusion Criteria:

• Diseases known to cause carpal tunnel syndrome: Diabetes mellitus, hypothyroidism, connective tissue disease, rheumatic disease and moderate or severe chronic renal impairment

• Secondary diagnosis based on the ultrasound: arthrosynovial cyst, flexor tenosynovitis, ganglion

• Constant symptoms in medial nerve area

• Thenar eminence atrophy

• Cervical radiculopathy

• Brachial plexopathy

• Thoracic outlet syndrome

• Polyneuropathy

• Pregnancy

• Cognitive disorder

• Anticoagulant therapy

• Carpal tunnel injection in the last 6 months

• Ancient ipsilateral wrist fracture

• Ancient ipsilateral wrist surgery