Combined Ketamine and Midazolam for Generalized Convulsive Status Epilepticus
Status:
Not yet recruiting
Trial end date:
2024-04-02
Target enrollment:
Participant gender:
Summary
Generalized convulsive status epilepticus (GCSE) is a common neurological emergency in
children. Benzodiazepines are the recommended first line antiseizure medication (ASMs), but
they fail to control seizures in a third of cases. Combination of benzodiazepines with
another ASM that has a different mechanism of action may be a promising option for faster
control of GCSE. In this study, we aim to evaluate the efficacy and safety of ketamine plus
midazolam versus midazolam alone as first-line therapy of pediatric GCSE.