Combined Mirtazapine and SSRI Treatment of PTSD: A Placebo-Controlled Trial
Status:
Completed
Trial end date:
2014-06-01
Target enrollment:
Participant gender:
Summary
The overall goal of this study is to examine the efficacy of the combination of mirtazapine
and sertraline in the treatment of posttraumatic stress disorder (PTSD). Sertraline is
FDA-approved for PTSD, but it is often not fully effective. The combination of mirtazapine
and serotonin reuptake inhibitors like sertraline has appeared highly effective in a related
disorder -- depression.
In this study, sixty patients with chronic PTSD will be randomized to treatment with either
sertraline + mirtazapine or sertraline + placebo for 12 weeks. Patients who show at least a
minimal response after 12 weeks will continue for another 12 weeks on the same treatment.