Combined Photodynamic and Pulsed Dye Laser Treatment of Port Wine Stains
Status:
Completed
Trial end date:
2014-10-01
Target enrollment:
Participant gender:
Summary
This research study was designed to determine the effect on port wine stains (PWS) of
liposomal benzoporphyrin derivative monoacid (BPD-MA) termed verteporfin by intravenous (IV)
infusion for photodynamic therapy (PDT) or combined PDT and pulsed dye laser (PDL) therapy
(PDT + PDL). The standard treatment for PWS is PDL alone. This lightens some PWS but many
lesions are not completely removed.
PDT uses a medication and light together to cause injury to a target. The medication is given
and then light is directed at the desired area of treatment to achieve an effect. PDT has
been used to treat some skin conditions including pre-cancers and skin cancers. Using PDT or
PDT immediately followed by PDL therapy may improve PWS lightening. At this time, both PDT
and PDT + PDL therapy for treatment of PWS is investigational. The type and amount of
medication and light which may be used to treat PWS is not known, and is likely to be
different than those used for other PDT treatments.
Phase:
N/A
Details
Lead Sponsor:
University of California, Irvine
Collaborator:
Beckman Laser Institute University of California Irvine