Combined Upper-airway and Breathing Control Therapies for Obstructive Sleep Apnea
Status:
Recruiting
Trial end date:
2021-06-01
Target enrollment:
Participant gender:
Summary
The current study combines two treatments for obstructive sleep apnea (OSA), oral appliances
and supplemental inspired oxygen. The following aims will be tested:
Aim 1. To determine whether supplemental inspired oxygen further reduces OSA severity
(apnea-hypopnea index) in patients using an oral appliance.
Aim 2. To determine whether baseline OSA phenotypes can predict the efficacy of oral
appliances versus supplemental oxygen versus both treatments in combination. We will test
whether responders to oral appliances have distinct pathophysiological characteristics
compared with oxygen responders.
Phase:
Phase 2
Details
Lead Sponsor:
Brigham and Women's Hospital
Collaborators:
American Heart Association Heart Foundation of Australia Monash University National Heart, Lung, and Blood Institute (NHLBI)