Combined Vasopressin, Methylprednisolone, and Epinephrine for Inhospital Cardiac Arrest

• Status: Completed
• Trial end date: 2007-04-01
• Target enrollment: 0
• Participant gender: All

Summary

A randomized controlled trial did not show benefit of vasopressin versus epinephrine in inhospital cardiac arrest. Preceding laboratory data suggest that combined vasopressin and epinephrine ensure long-term survival and neurologic recovery. Also, postresuscitation abnormalities mimic severe sepsis. The investigators hypothesized that combined vasopressin and epinephrine during cardiopulmonary resuscitation (CPR), and steroid supplementation during and after (when required) CPR may improve survival in cardiac arrest.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Athens
• Treatments: Arginine Vasopressin; Epinephrine; Epinephryl borate; Methylprednisolone; Methylprednisolone acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate; Racepinephrine; Vasopressins

Criteria

Inclusion Criteria:

• Adult in-patients with cardiac arrest requiring epinephrine according to current guidelines.

Exclusion Criteria:

• Age < 18 years.

• Documented terminal illness (life expectancy < 6 weeks).

• Do not resuscitate status.

• Cardiac arrest before arrival at hospital.

• Prior enrollment into the study (i.e. second or third inhospital arrest etc.).

• Corticosteroid treatment before the cardiac arrest.

• Any inaccurate documentation of CPR data such as medication, number of countershocks etc.