Combining Antidepressant Medication and Psychotherapy for Insomnia to Improve Depression Outcome

• Status: Completed
• Trial end date: 2007-08-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will examine the effectiveness of a combination of antidepressant medication and sleep-focused psychotherapy to simultaneously treat sleep difficulties and depression.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Stanford University
• Collaborator: National Institute of Mental Health (NIMH)
• Treatments: Citalopram; Dexetimide

Criteria

Inclusion Criteria:

• Diagnosis of major depressive disorder

• HRSD(17) score of at least 14

• Presence and complaint of insomnia for at least 1 month

• Fluent in English

• Use of an effective form of contraception throughout the study

Exclusion Criteria:

• Other psychiatric disorders (e.g., bipolar disorder, post traumatic stress disorder, obsessive compulsive disorder, eating disorder)

• Psychotic symptoms

• Serious, unstable, or terminal medical condition

• Axis II diagnosis of antisocial, schizotypal, or severe borderline personality disorder

• Substance abuse

• Not willing to end other psychiatric treatment

• Previous electroconvulsive therapy or vagus nerve stimulation treatment during the last year

• Sleep apnea, restless leg, or periodic limb movement disorder (to be ruled out after first sleep study)

• Other sleep disorders

• Currently pregnant or breastfeeding

• History of seizure disorder

• Disease or condition that produces altered metabolism or hemodynamic responses

• Liver or kidney dysfunction

• Current use of any over the counter medications or herbs for mood or sleep benefits (e.g., melatonin, valerian, kava, hop extract, St. John's Wort, SAMe)