Overview

Combining Low Oxygen Therapy and an Adenosine A2a Receptor Antagonist to Improve Functional Mobility After Spinal Cord Injury

Status:
Not yet recruiting

Trial end date:
2027-06-30

Target enrollment:

Participant gender:

Summary

Breathing brief, moderate bouts of low oxygen (acute intermittent hypoxia, AIH) trigger spinal plasticity and improve walking function after spinal cord injury (SCI). However, extracellular adenosine accumulates during hypoxia exposures and may undermine the efficacy of AIH training-induced walking recovery. The goal of the study is to understand how caffeine may augment the effects of AIH training on walking recovery and spinal plasticity (the ability of the nervous system to strengthen neural pathways based on new experiences) following SCI.

Phase:

Phase 1/Phase 2

Details

Lead Sponsor:

Randy Trumbower, PT, PhD

Treatments:

Istradefylline