Comedone Extraction and Oral Doxycycline In The First Line Treatment of Moderate Acne Vulgaris
Status:
Completed
Trial end date:
2015-10-14
Target enrollment:
Participant gender:
Summary
The objective of the study was to evaluate the effectiveness of comedone extraction compared
to oral antibiotics as the main therapy of moderate acne vulgaris (MAV); and to determine the
expression of HIF-1 alpha by examining the immunohistochemistry and ELISA as a sign of
hypoxia/anoxia in MAV lesion. This was a randomized, placebo-controlled clinical trial that
was performed in 2015 at three different dermatology clinics in Indonesia, Cipto Mangunkusumo
Hospital Jakarta, Gatot Soebroto Army Hospital Jakarta, and PT. Mattel Indonesia, Cikarang.
One hundred and twenty eight subjects with moderate acne vulgaris were recruited and
randomized to receive either oral doxycycline or comedone extraction for six weeks. Subjects
who had acne lesion and the back area were offered skin lesion biopsy to evaluate
immunohistochemistry and ELISA before administration of medication. The main outcome was
total reduction of inflammatory and non inflammatory lesions, evaluated every two weeks.