Community-Acquired Pneumonia : Evaluation of Corticosteroids

• Status: Recruiting
• Trial end date: 2022-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Mortality of severe Community-Acquired Pneumonia (CAP) has not declined over time and is between 25 and 30% in sub-groups of patients. Corticosteroids (CTx) could down-regulate pulmonary and systemic inflammation, accelerate clinical resolution and decrease the rate of inflammation-associated systemic complications. Two recent meta-analyses suggest a positive effect on severe CAP day 28 survival when CTx are added to standard therapy. However they are based on only four trials gathering less than 300 patients, of which only one was positive. Recently published guidelines do not recommend CTx as part of CAP treatment. Therefore a well-powered trial appears necessary to test the hypothesis that CTx - and more specifically hydrocortisone - could improve day 28 survival of critically-ill patients with severe CAP, severity being assessed either on a Pulmonary Severity Index ≥ 130 (Fine class V) or by the use of mechanical ventilation or high-FiO2 high-flow oxygen therapy.

A phase-III multicenter add-on randomized controlled double-blind superiority trial assessing the efficacy of hydrocortisone vs. placebo on Day 28 all-causes mortality, in addition to antibiotics and supportive care, including the correction of hypoxemia.

Randomization will be stratified on: (i) centers; (ii) use of mechanical ventilation at the time of inclusion.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital, Tours
• Treatments: Cortisol succinate; Hydrocortisone; Hydrocortisone 17-butyrate 21-propionate; Hydrocortisone acetate

Criteria

Inclusion Criteria:

• Age ≥ 18 years

• Patients affiliated to social security scheme

• Admission to an Intensive Care Unit (ICU) or intermediate care unit participating to the trial

• Diagnosis of Community- Acquired Pneumonia (CAP) suggested by at least two of the following: cough, purulent sputum, chest pain and dyspnea

• Focal shadowing/infiltrate on chest X-ray or CT-scan

• Diagnosis of Community- Acquired Pneumonia (CAP) during the 48 hours post-hospital admission

• Study drug infusion initiated no longer than 24 hours post first severity criterion

• Severity defined by at least one of the following:

• Pneumonia Severity Index (PSI) > 130 (Fine class V)

• Patient placed on mechanical ventilation (invasive or not) for acute respiratory failure, with a PEEP level of 5 cm of water or more

• Patient treated by high-flow oxygen therapy with a FiO2 of 50% or more and a P/F ratio less than 300

• Patient treated by oxygen therapy with a partial rebreathing-mask with a reservoir bag, provided that the PaO2 is less than (cf. table):

Oxygen flow (L/min) 6 7 8 9 10 or more PaO2 (mmHg) less than 180 210 240 270 300

• Patient already treated by antibiotics (at least one dose since admission to hospital)

• Informed consent signed by the patient, its relatives or emergency procedure

On the sub-group of patients included with COVID19 :

• Diagnosis of COVID19 either as certain (PCR) or probable (evocative clinical and radiological features AND epidemic context AND absence of other microbiological documentation).

• Study drug infusion initiated no longer than 24 hours post first severity criterion ; in case of transfer from another hospital, this period will be prolonged to 48 hours

• Patient receiving the best available treatment as define by up-to-date scientific knowledge

Exclusion Criteria:

• Patient treated by vasopressors for septic shock at the time of inclusion

• Clinical history suggesting of aspiration of gastric content

• Patient treated by invasive mechanical ventilation within 14 days before current hospital admission

• Patient treated by antibiotics for a respiratory infection for more than seven days at the admission to the hospital (except if a pathogen resistant to this antibiotics is isolated)

• History of cystic fibrosis

• Post-obstructive pneumonia

• Patients in which rapid PCR-test is positive for flu

• Active tuberculosis or fungal infection

• Active viral hepatitis or active infection with herpes viruses

• Myelosuppression

• Decision of withholding mechanical ventilation or endotracheal intubation

• Hypersensitivity to corticosteroids

• Patient needing anti-inflammatory corticosteroids or substitutive hydrocortisone for any reason

• Patients under treatment by more than 15 mg/d of prednisone (or equivalent) for more than 30 days

• Patient already enrolled in another drug trial with mortality as an end-point. If the patient is already participating in another therapeutic trial with a different endpoint, the investigator must verify that inclusion in CAPE COD can not prejudice it.

• Pregnant or breastfeeding woman

• Patient on judicial protection