Comparation Analgesia Efficiency With Propofol Combine Sevoflurane vs Propofol

• Status: Completed
• Trial end date: 2020-07-01
• Target enrollment: 0
• Participant gender: All

Summary

This study purpose to compare analgesia efficiency of propofol combine with sevoflurane with propofol only using index of Nociception (NOX)

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: China International Neuroscience Institution
• Treatments: Propofol; Remifentanil; Sevoflurane; Sufentanil

Criteria

Inclusion Criteria:

• Participants were aged 18-65 years old,

• American Society of Anesthesiologists (ASA) physical status I, II or III

• scheduled to have urological surgery(would last longer than 1 h)

• requiring general anesthesia.

Exclusion criteria:

• refused to participate in this study;

• Unable to communicate normally because of consciousness alterations;

• a history of allergy to opioids

• contraindications to inhalational anesthesia

• a family history of malignant hyperthermia

• a history of alcohol or drug abuse

• received central nervous system-active drugs

• super obese as defined by a body mass index ≥40 kg/m2

• conditions liable to alter the pharmacokinetic and pharmacodynamic behaviors of the intravenous and inhalation anesthetics

• previous head injury

• neurologic

• psychiatric disease

• any disabling central nervous

• cerebrovascular disease

• using psychoactive

• anti-convulsive medications at the time

• unstable angina

• manifested congestive heart failure

• expected difficulty airway management