Comparative Analgesic Effects of Paracetamol/Codeine and Ibuprofen on Pain After Third Molar Surgery

• Status: Completed
• Trial end date: 2020-10-14
• Target enrollment: 0
• Participant gender: All

Summary

To compare analgesic effects of preoperative administration of paracetamol 500 milligram plus codeine 30 milligram in single-tablet and effervescent formulation to ibuprofen 400 milligram, and placebo in the management of moderate to severe postoperative pain after mandibular third molar surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Roma La Sapienza
• Treatments: Acetaminophen; Codeine; Ibuprofen

Criteria

Inclusion Criteria:

• healthy status (ASA class I);

• nonsmoker;

• not pregnant or breastfeeding;

• no medication consumption in the past 21 days;

• good oral hygiene;

• bony impaction of one mandibular third molars;

• the presence of the first and second molars;

• compliance to cooperate with the research protocol.

Exclusion Criteria:

• chronic systemic disease;

• medications with potential interaction to paracetamol-codeine or ibuprofen;

• a history of intolerance or hypersensitivity to the study drugs;

• any pre-existing pain and acute inflammatory or infectious conditions; - inability to understand or perform the study procedure.