Comparative Effectiveness Research Trial for Antidepressant Incomplete and Non-responders With TRD
Status:
Recruiting
Trial end date:
2022-01-01
Target enrollment:
Participant gender:
Summary
This is a multi-site, randomized, open-label, effectiveness trial comparing three treatment
arms for Major Depressive Disorder (MDD) patients with TRD who are currently on ongoing,
stable and adequate antidepressant therapy (ADT). Adequate ADT is defined as a
therapeutically sufficient dose for a sufficient treatment period, which would be expected to
be effective as listed in the MGH Antidepressant Treatment Response Questionnaire (ATRQ).
Patients will be randomized in a 1:1:1 fashion to one of three open-label treatment arms: a)
aripiprazole augmentation, b) rTMS augmentation, and c) switching to venlafaxine XR or
Duloxetine.