Comparative Effectiveness of 30%TSC and Heparin Lock Solution in Hemodialysis Catheters
Status:
Completed
Trial end date:
2014-07-01
Target enrollment:
Participant gender:
Summary
BACKGROUND: Central venous catheters (CVC) are the only option when hemodialysis is needed
for patients without definitive vascular access. However, CVC use is associated with
complications such as infection, thrombosis, and dysfunction, leading to higher mortality and
expenditures. The aim of this study was to compare the effectiveness of 30% trisodium citrate
(TSC30%) with heparin as CVC lock solution in preventing catheter-related bloodstream
infections (CRBSI) and dysfunction in hemodialysis patients. METHODS: Randomized,
double-blind controlled trial comparing the event-free survival of non-tunneled CVC locked
with heparin or TSC30% in adult hemodialysis patients.