Comparative Efficacy of Phenylbutyrate (PBA) vs. Benzoate in Urea Cycle Disorders
Status:
Completed
Trial end date:
2015-10-01
Target enrollment:
Participant gender:
Summary
The investigators will study and compare how effectively sodium phenylbutyrate, sodium
benzoate, and a combination of the two, help excrete nitrogen in healthy volunteers. Subject
participation will require three, separate, four-day study periods at least one week apart.
During one study period (also called a treatment arm), subjects will take sodium
phenylbutyrate; during another they will take sodium benzoate; during another they will take
a combination of the two medications.
We expect to find that phenylbutyrate is more effective at removing nitrogen than benzoate or
a combination of the two.