Comparative Evaluation of Herbal and Allopathic Drugs for the Treatment of Chronic Diarrhea

• Status: Completed
• Trial end date: 2015-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Revival of significance and the emergent market of herbal medicinal products necessitate strong commitment by the stakeholders to safeguard the end users. The variability in the concentrations of constituents of plant material, coupled with the variety of extraction techniques and processing steps used by different manufacturers, results in distinct inconsistency in the quality of herbal products. The present study will be directed to a polyherbal formulation Entoban which integrates an outstanding blend of herbs that have been used for decades to eradicate microorganisms and worms from gastrointestinal tract. It is the combination of Holarrhena antidysenterica, Berberis aristata, Symplocos racemosa, Querecus infectoria and Helicteres isora. The current study would target the chemical assessment, pharmacological and comparative clinical evaluation of Entoban to assure its safety and efficacy.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Shifa Ul Mulk Memorial Hospital
• Treatments: Metronidazole

Criteria

Inclusion Criteria:

• Male or female adults between the age of 18-60 years who were suffering from diarrhea of presumed infectious origin and willing to participate were eligible for inclusion in the study.

Exclusion Criteria:

• Exclusion criteria were the presence of chronic

• Iatrogenic, or bloody diarrhea, having received antibiotic treatment for other medical or surgical problems

• Having a history of renal or hepatic dysfunction

• Having a concomitant infection.

• Patients receiving treatment with an anti-diarrheal drug in the five days prior to the study were also excluded.

• Pregnant or lactating women and women planning pregnancy were also ineligible for study participation.