Comparative Study Between Minidose Long Protocol and Microdose Flare Protocol in Controlled Ovarian Hyperstimulation
Status:
Completed
Trial end date:
2011-12-01
Target enrollment:
Participant gender:
Summary
Objective: To compare two stimulation protocols, the minidose long protocol and the microdose
flare protocol designed for low responders undergoing ICSI.
Design: Randomized prospective study. Setting: University hospital IVF unit. Patients: 60
poor responder patients coming for IVF center for ICSI. Interventions: Minidose long protocol
in which half the dose of agonist was administered from the mid luteal phase until the day of
HCG administration was compared with microdose flare protocol in which half the dose of GnRH
was administered from the second day of the cycle until the day of HCG administration. Both
groups received Gn stimulation from the second day of the cycle (300-450 IU).
Main outcome measures: Number of oocytes retrieved.