Comparative Study Between the Efficacy of Verapamil and Bisoprolol on Reduction of Bleeding During Endoscopic Sinus Surgery Under General Anaesthesia.

• Status: Not yet recruiting
• Trial end date: 2021-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The study aims to compare the effect of addition of verapamil and Bisoprolol to general anasthesia aimed reduction in heart rate and blood loss during endoscopic sinus surgery.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Assiut University
• Treatments: Bisoprolol; Verapamil

Criteria

Inclusion Criteria:

• Age of 18 - 60 years.

• patients of both genders.

• ASA grade I - II.

Exclusion Criteria:

• Patient refusal.

• Any contraindication of B- blocker:

1. Athma , COPD

2. Bradycardia , Heart block

3. Acute decompensated heart failure

4. Peripheral vascular disease

• Any contraindication of calcium channel blocker:

1. AV conduction defects (2nd and 3rd degree AV block).

2. Sick sinus syndrome .

3. Wolf-Parkinson-White Syndrome.

4. History of congestive heart failure.

5. Patients on long-term ß-blocker therapy.

6. Patients with allergy to medication included in the study.