Comparative Study: Vaginal Promestriene Use, Fractional CO2 LASER and Radiofrequency in the Vaginal Atrophy Treatment
Status:
Completed
Trial end date:
2020-02-18
Target enrollment:
Participant gender:
Summary
Postmenopausal hypoestrogenism may determine genital atrophy, which may be accompanied by a
non-specific inflammatory process and may hinder or even prevent sexual intercourse. In more
severe cases, the patient may have local pain that interferes with their daily activities.
The best treatment for increasing genital trophism is still estrogen. However, there are
women who can not use this therapy or do not want it. Therefore, there is a need for
alternatives, such as ablation techniques: use of CO2 LASER and fractional radiofrequency.
The study was carried out at the outpatient clinic of Lower Genital Tract ambulatory of the
Discipline of Gynecology, Department of Obstetrics and Gynecology, Clinical Hospital, Faculty
of Medicine, University of São Paulo, involving 75 women who were divided after randomization
in three groups:
Group 1 - treatment with topical vaginal promestriene (n = 25 patients); Group 2 - treatment
with fractional CO2 LASER (n = 25 patients); Group 3 - fractional microablative
radiofrequency treatment (n = 25 patients).
An evaluation of the complaints were be performed through questionnaires on sexuality,
quality of life and urinary incontinence, as well as biopsies of the vaginal wall for
histomorphometric, immunohistochemical and molecular biology study before and after six
months of treatment. The duration of the study were fifteen months.